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Cord Blood Goes Missing

Where are my child's stem cells?

That's what 200-300 Dutch parents were asking when they discovered Cryo-Save was on the brink of bankruptcy and had transferred their children's umbilical cord cells long-term cryo storage to the PBKM FamiCord Group in Poland. A FamiCord representative confirmed that 2% of approximately 230,000 clients’ samples did not arrive at the laboratories. Cryo-Save now faces a transplant law investigation in response to transporting these samples without the client's consent. READ MORE

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Heart Preservation Breakthrough

The ULiSSESTM device won the 2019 grand prize for the "Create the Future" Design Contest, an annual competition hosted by Tech Briefs Media Group and has now been put to the test. Developed over decades by teams at the Univerisity of Austin and Vascular Perfusion Solutions, this device could increase the transportation time of donor's hearts and other vital organs from 4 hours to 24 hours. 

The ability to preserve donor organs for 24 hours would revolutionize organ transplants, creating an opportunity for organs to be transported around the world. With five successful 24-hour trials on pig heart preservation and one dog heart preservation, the next ULiSSESTM trials will involve pig heart transplants with a goal to move into human trials by 2021. READ MORE

Special Announcement: ASRM Committee Opinion

The American Society for Reproductive Medicine (ASRM) recently announced in a committee opinion that ovarian tissue cryopreservation (OTC) is no longer considered experimental and can be used in prepubertal patients or when there is not time for ovarian stimulation. This is a major step for the field and provides young patients with more options to preserve their future fertility.

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Call for 2023 Meeting Locations

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Thank you and Farewell from Outgoing President, Dayong Gao

As my term as President of the Society for Cryobiology draws to a close, I would to express my deep appreciations and to reflect on the achievements of our society during the previous two years. 

Firstly, my sincere thanks go to my fellow Board of Governors, and particularly the Executive Committee members: Dr. Adam Higgins (President-Elect), Dr. Andy Shu (Treasurer) and Dr. Yuksel Agca (Secretary). The Executive and Board of Governors give their time freely and generously for the betterment and advancement of the Society, for which we cannot thank them enough. 

I would also like to acknowledge and thank Executive Director, Nicole Evans, for her continued and distinguished work in leading planning, development and administration for the Society. I must also thank the tireless and outstanding work of Dr. David Rawson, Editor-in-Chief, of Cryobiology and the excellent Editorial Board, who contribute their tremendous time and efforts to review the journal’s submissions to ensure the high quality and publication standard.

The Society has made many great strides during my term as President. I am exceptionally proud to have overseen the introduction of two new awards of our Society, both inaugurally awarded in 2019. Firstly, the Dayong Gao Young Investigator Award (sponsored by the GoldSim) to recognize a most outstanding young researcher in their early career, and secondly, the Arthur W. Rowe Cryobiology Best Paper Award, to recognize the most outstanding research article published in the journal each year. Furthermore, the Board of Governors is currently finalizing the Peter Mazur Prize (a Lifetime Achievement Award), which will recognize individuals who have reached the highest level of devotion and achievement in the field of cryobiology. 

I have continued to focus on forging new collaborations and strengthening and renewing familiar ties, with a number of signed memorandums of understanding (MOUs) with ISBER, ISCT, Knect365, and others. One of the most exciting collaborations of the last two years has been the co-publication with ISBER of the freely downloadable Liquid Nitrogen Best Practices Addendum. If you have not yet had the chance to read it, I highly recommend it.

With regard to the Annual Meeting, the Society for Cryobiology has now completed the transition period from local organizing committee to in-house organization, with Nicole leading logistics for CRYO2018 in Madrid, and logistics and fundraising for CRYO2019 in San Diego. She will continue to lead logistics and fundraising for CRYO2020 in Chicago, and beyond. One of her current focuses is to establish and cement relationships with key industry individuals to secure the financial viability and profitability of the meeting.  

As cryobiologists, we are entering a new era when cryobiology has a unique and significant contribution and impact on almost every major biological/biomedical research and application area. A once opaque science shrouded in mystery (and liquid nitrogen vapors!) has captured the attention of the public through mainstream news/articles on tissue engineering, biobanking, cellular-gene therapy, artificial organs, tissue-organ transplantation, regenerative medicine, and precision-personalized medicine. With this diverse range of applications and growing public acknowledgement, this is an exciting time for the field, its scientists and end users, and the Society for Cryobiology.

Lastly, I must thank you, our members for electing me to the position of President and allowing me the opportunity to lead the Society for Cryobiology. As each President builds upon the momentum of his predecessor, I trust I leave the Society healthy, strong, and resilient for new incoming President, Dr. Adam Higgins, who takes the reins 2020-2021. 

I wish you all a Merry Christmas and Happy New Year! 

Cheers,

Dayong Gao, Ph.D
President,
Society for Cryobiology
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SLTB Report

Written by Estefania Paredes (University of Vigo, ES), Dominic Olver (University of Saskatchewan, CA), Peter Kilbride (Asymptote Ltd., UK)
The Society for Low Temperature Biology annual meeting took place in the sunny and welcoming city of Seville (Spain) for its 55th edition in October 2-4th, 2019. The meeting started with a workshop in collaboration with the Stem User group (SCUG) and the Andalusian Initiative for Advanced therapies.

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British Woman Survives 6 Hours After Cardiac Arrest

A recent hiking trip turned frigid after thirty-four-year-old Audrey Schoeman and her husband Rohan got caught in a snowstorm in the Pyrenees mountain range, Spain. Rohan called emergency services after Schoeman passed out. 

Dr. Jordi Riera and the team at Vall d'Hebron explained that Schoeman's extreme and rapid cooling to 18°C, causing her cardiac arrest, also slowed her brain metabolism which allowed the organs to better cope with the lack of oxygen. The team used an extracorporeal membrane oxygenation (ECMO) machine to keep her alive. Warming up slowly, Schoeman regained consciousness 6 hours after her cardiac arrest. Despite some loss of sensitivity in her hands, Schoeman has made a full recovery and returned home. Read the full article. 

This "miracle" is the sort of biological phenomenon the team at the University of Maryland is attempting to duplicate with acute trauma victims. Read more...




First HIV Positive Sperm Bank Opened

Just before World Aids Day on December 1st, New Zealand just became the first country to establish a sperm bank called Sperm Positive for HIV positive donors who have a consistently undetectable viral load. Damien Rule-Neal, one of the first donors, said: "I want people to know life doesn't stop after being diagnosed with HIV and that it is safe to have children if you're on treatment." Read the full article HERE.

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First Human Placed in Suspended Animation

A team of medics at the University of Maryland, School of Medicine have announced their first attempt at placing a human in suspended animation. The Federal Drug Administration approved the team for 10 trials where a patient will be rapidly cooled to 10-15 °C by replacing their blood with ice-cold saline, ceasing nearly all brain activity. Hypothetically, medical professionals then have up to 2 hours to operate before the "suspended" patient is rewarmed and their heart started again. The team's trial procedure officially called Emergency Preservation and Resuscitation (EPR), is only allowed to be trialed on acute trauma victims (i.e. gunshot or stab wounds) who have already suffered cardiac arrest and have less than a 5% survival rate.
Read the full article HERE.

Election Results

The results are in from the 2019 Election, and we are pleased to notify members of the following results: 



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Health & Safety - Liquid Nitrogen Injuries Continue

 
A woman in Florida, USA, nearly died in October 2019 after ingesting a drink with liquid nitrogen. Ms. Stacey Wagers saw a waiter pour a liquid onto another patron's dessert, giving it a neat "smoky" effect. The waiter poured some of the same liquid into Wager's glass of water after her friend commented on the cool effect. Wager became immediately and violently ill, resulting in her gall bladder and parts of her stomach being removed. Read more...

2019 Election

2019 Elections

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CRYO2019 Plenary Speakers in the News

CRYO2019 Plenary speakers Bart Panis and Oliver Ryder have featured in a recent news article by Katharine Gammon, a freelance science writer in California, who attended CRYO2019 as our guest. Ryder, the director of the "Frozen Zoo", presented on the continuous efforts made by the San Diego zoo to cryopreserve genetic material from over 10,000 species. Panis, a senior researcher with the Leuven, Bioversity International, discussed with Gammon the massive ice cave-turned-seed bank, Svalbard seed vault, with its 820,000 seed samples and the challenges surrounding flora cryopreservation. Read the full article HERE

Organ Transplant Survival Rate to Triple

Researchers from Massachusetts General Hospital and Harvard Medical School began supercooling rat livers 5 years ago with the intention of being able to preserve human organs for more than the current 9 hours. Society for Cryobiology members, Reinier de Vries and Korkut Uygun, contributed to the research team's current experiment on human livers that were unsuitable for transplants. The research team's ultimate goal is a true organ bank where organs can be preserved for years instead of hours or days and in essence, eliminate the hundreds of deaths that occur while patients wait for a suitable transplant. Read the full article HERE.

Death of Igor Katkov

Igor KatkovIt is with sadness that we must inform members and the wider cryobiology community of the sudden and unexpected death of Prof. Igor Katkov in early September 2019. At the time of his death Prof. Katkov was serving a term as Governor on the Society for Cryobiology's Board. 

Prof. Katkov received his education as a Biophysicist in the former “Cryobiological Capital of the World” Kharkov, Ukraine (to use Igor's wording). After completing his PhD on the correlation between the tolerance of bovine sperm to electroporation and freezing, Prof. Katkov undertook a post-doctoral fellowship with Peter Mazur at Oak Ridge National Laboratory (1996-1998), researching osmotic and cryotolerance of mouse sperm. He then went on to work with Victor Bronshtein in San Diego, researching high temperature vitrification by drying without lyophilization. 

From 2001 - 2007 he worked at the University of California, San Diego (department of Pediatrics), developing a technique of freezing adherent pluripotent stem cells directly in multi-well dishes. During this time he developed a novel Relativistic Permeability approach, which calculates the exact level of maximum shrinkage during freezing and swelling during dilution. He was the first person to show that a permeable solute may behave paradoxically and have a bi-phasic pattern: moving in and then out during addition (hypersaturation effect) and out and back in the cell during dilution (hyperdiliution effect). In 2001 Prof. Katkov also founded Celltronix and served as Chief Scientific Officer, and from 2015 he combined this with the role of Head of the Laboratory of Amorphous State at Belgorod University (Russia) - serving in both roles until his death. Prof. Katkov’s most recent work has been the development of the concept of and building equipment for kinetic vitrification by hyperfast cooling, namely designing the K-VF KrioBlast™ in cooperation with V. F. Bolyukh from Ukraine.

In 2012 Prof. Katkov edited Current Frontiers in Cryobiology and Current Frontiers in Cryopreservation, the first major update to cryobiology literature since the publication of Life in the Frozen State (2004). During his career he published more than 160 research articles, and was granted 5 patents in the United States and Russia. 

To send a message of condolence please contact Nicole Evans who will pass all messages on to Prof. Katkov's family.

CRYO2019 Report

CRYO2019, the 56th Annual Meeting of the Society for Cryobiology, took place recently July 22-25 in San Diego. 

As climate change and population growth are of increasing global awareness and concern, CRYO2019 opened with a special conservation session detailing current research activities in preservation of genetic material from wild animal and plant species and agriculturally important crops. Speakers included Oliver Ryder, Kleberg Endowed Director of Conservation Genetics at The Frozen Zoo® of San Diego Zoo's Institute for Conservation Research, giving an overview on the Frozen Zoo's past, present and future conservation research and activities; Hugh Pritchard, Senior Research Scientist in Comparative Seed Biology, at the Royal Botanic Gardens, Kew (UK), speaking on the importance of cryobiotechnology for conservation of wild plant species; and Bart Panis, senior scientist at KU Leuven (Belgium), on the realizations and challenges of ensuring the world's food supply through cryopreservation of vital crops, such as bananas, cassava, potatoes, and sweet potatoes. These topics were further explored throughout the meeting in a number of related sessions including animal conservation and germplasm preservation, and plant cryobiotechnology. 

San Diego and the surrounding area is a well known biotechnology hub, and for this reason the second day of the meeting featured a dedicated cell therapy track, featuring a number of academic and industry speakers, including plenary speakers Robert Tressler, Vice President of the San Diego Blood Bank, and John Elliott, Principal Investigator at the National Institute of Standards and Technology (NIST). Session themes throughout the day included preservation of cellular therapies and good manufacturing practice in cell therapy manufacturing development and commercialization, with industry speakers from Kite Pharma, GE Healthcare, Fate Therapeutics, BioLife Solutions, and Juno Therapeutics, among others. 

Multiple sessions in fundamental cryobiology topics, cell and tissue preservation, tools and technologies, natural adaptation, and thermal medicine rounded out the scientific program, alongside several sessions organized in collaboration with the Organ Preservation Alliance and the International Society for Biological and Environmental Repositories (ISBER). Full program information can be viewed at cryo2019.com/schedule

During the meeting the Society for Cryobiology was pleased to announce the inaugural winners of two recently established awards, the Dayong Gao Young Investigator Award, named after current Society President and sponsored by GoldSim, which gifts $5,000 to a young researcher in the first 10 years of their post-PhD career, and the Arthur W. Rowe Cryobiology Best Paper Award, awarded to an outstanding research article published in the preceding year in Cryobiology, as decided by the journal's editorial board. 

The inaugural winner and recipient of the Young Investigator award was announced as Leandro Godoy, Associate Professor at the Federal University of Rio Grande do Sul, Brazil, for his research on the application of biotechnologies to reproduction of aquatic organisms, the development of protocols for gamete and embryo cryopreservation and the effects of cryopreservation on reproductive cells metabolism. His research has applications in both aquaculture and conservation of endangered aquatic species through the establishment of germplasm banks. Dr. Godoy, who is leader of the ReefBank Project, plans to use the $5,000 honorarium for the ReefBank Project, specifically to assist with creating the first bank of coral gametes in the South Atlantic Ocean. 

Arthur W. Rowe, founding member of the Society, and Cryobiology editor-in-chief for 24 years, delivered a presentation on the journal's history before the announcement of the winner of the eponymous best paper award - James D. Benson (University of Saskatchewan) et al. for "A toxicity cost function approach to optimal CPA equilibration in tissues" Cryobiology vol. 80. This research explores a numerical approach to adapt cell-based CPA equilibration damage models for use in a classical tissue mass transport models, and found that there are fundamental differences between protocols designed to minimize total CPA exposure time in tissues and protocols designed to minimize accumulated CPA toxicity. 

CRYO2020 will take place July 21-24, 2020 in Chicago. 

Postponing Menopause

Springboarding off the research done to preserve female's fertility before cancer treatments, researchers are now applying the same techniques to women in an attempt to postpone menopause. Researchers remove an ovarian tissue sample, use cryopreservation to preserve the pre-menopausal tissue, and then, even decades later, thaw and graft the tissue back onto the body. This tissue can then restore the reduced hormones and delay menopause. Tissue samples from nine women are being preserved, ready to be used just as the women begin to enter menopause.

Of course the younger and healthier the original tissue sample, the more effective it will be in delaying menopause. A tissue sample from a 40-year-old woman is expected to delay menopause by only 5 years, but future women in their 20s may be able to postpone menopause or even extend their fertility window by 20 to 30 years. READ MORE...

The First Lunar Colonist!

You shouldn't expect any Lunar base construction yet; the first know lunar "colonists" are Tardigrades. These microscopic "water bears" can survive in nearly all of Earth's extreme environmental conditions - boiling, freezing, high pressure, and vacuum - everything except ultraviolet radiation. 

An experiment about the Tardigrades' adaptability to space literally crash-landed during the Israeli moon mission, Beresheet, on April 11th, scattering the thousands of tiny creatures across the moon's surface. However, without the presence of liquid water their survival rate is next to zero. READ MORE...

Death of David Pegg

It is with sadness we have to pass on news of the recent death of Prof. David Pegg at his home in York, United Kingdom on Saturday August 3, 2019. He was 86 years old.

Prof. Pegg completed a Bachelor of Science and Medical Degree at the University of London in 1956, and followed this with a Doctorate in Medicine in 1963 from the same institution. The early part of his career was spent at Westminster Medical School in Clinical and Lecturing posts, before spending the major part of his career based in Cambridge at the Medical Research Council (MRC) Clinical Research Centre (1968 - 1978) and then as Head of the MRC Medical Cryobiology Group (1978 - 1992). Prof. Pegg then moved to York, as Director of the Medical Cryobiology Unit at the University of York. Prof. Pegg was an advisor to the UK's National Blood Service, Department of Health, and Human Embryology and Fertilization Authority. He also served as Chairman of the Society for Low Temperature Biology, Prof. Pegg trained a number of prominent British and international cryobiologists, including former Associate Editor of Cryobiology, W. John Armitage (University of Bristol), Barry Fuller (University College London/Royal Free Hospital), Mike Taylor (Sylvatica Biotech/Carnegie Mellon University).

Prof. Pegg is well-known as a great cryobiologist who made outstanding contributions to the science of cryobiology and to the Society for Cryobiology. He was a founding member of the Society for Cryobiology and served the Society as President (1974-1975), Governor (several terms), and Editor-in-Chief of Cryobiology (1994 - 2011). He was elected as a Fellow of the Society for Cryobiology in 2005. Prof. Pegg's primary research interests focused on tissue and organ cryopreservation. Recent research projects had included work on corneas, cartilage, blood vessels, cardiac valves, and tissue-engineered graft materials. He was interested in not only the fundamental mechanism of freezing injury, but also the development of novel cryopreservation techniques and their clinical applications. He authored and/or edited six books and more than 200 journal papers in the field of cryobiology.

A memorial ceremony in celebration of Prof. Pegg's life will take place on Thursday 29th August in York, UK. 

Sincerely, 
Nicole Evans, Executive Director
Dayong Gao, President 

Society for Cryobiology

Are We Ready for Space Babies?

We don't have to worry about our planetary passports quite yet. As a species, we're still "light years" away from space babies, but the  European Society of Human Reproduction and Embryology in Vienna presented research that frozen sperm samples can still be viable after being subject to microgravity conditions.

Montserrat Boada, director of an embryology laboratory at Dexeus Mujer, a women's health center in Barcelona, Spain and a team of researchers tested the effects of altered on sperm samples using aerial abcroatics. Passenger air flight is no comparison to the conditions these 10 sperm samples underwent which included at least 20 parabolic maneuvers that exposed the samples to space-like gravity and gravity forces two to three times more than experienced on Earth.  Other obstacles to future space colonization would include conception, the effect of microgravity on respiratory and circular systems, and the unknown prenatal effect of zero-Gs. Read more HERE