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2018 Election


Top: John G. Baust, Rob Ben, Ali Eroglu
Botton: Xiaoming "Shawn" He, Peter Kilbride, Estefania Paredes, Gang Zhao

This year's Society for Cryobiology election will be held October 15-29, 2018.  The election is for three Governor-at-Large positions for a three year term, commencing January 2019 and ending December 2021.

DOWNLOAD CANDIDATE BIOGRAPHIES

Meet the candidates







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SLTB 2018 Meeting Report 

Guest Post by Alasdair Kay, University of York, United Kingdom 

Prague 6-7th September 2018

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New Website Consultation

 The Society for Cryobiology's main website is having a face lift, and we're taking this opportunity to rethink the menu structure and content.

View the proposed changes and have your say. 

PROPOSED NEW MENU STRUCTURE 

Additionally, if you'd like to get involved with content creation, either by contributing to the proposed new pages or through a guest blog/event report or anything else you can think of - let Nicole know! Member contributions for the website and newsletter are strongly encouraged. 





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Pierre Boutron Named CryoFellow

Pierre Boutron has recently been announced as the 2018 Society for Cryobiology Basil J. Luyet CryoFellow.

Pictured Above: Society for Cryobiology President, Dayong Gao, presents Pierre Boutron with the Basil J. Luyet Fellow Medal during the opening ceremony of CRYO2018, held July 10, 2018. 

Dr. Boutron is recognized today as the man who taught us how to understand the amorphous, or non-crystalline, state of solutions of cryoprotective agents, however as early as 1978 he was also the first person to envision achieving vitrification at low cooling rates using high concentrations of cryoprotectants. That was one reason he sought to understand the conditions required to prevent significant quantities of ice from forming during either cooling or warming. It was also the reason he set out to discover novel cryoprotectants that would favor vitrification. 

In his 1978 manuscript 'Stability of the Amorphous State in the System Water-Glycerol-Dimethylsulfoxide' published in Cryobiology lengthy tables show in great detail the amount of ice formed in different solutions at different warming rates and temperatures based on differential scanning calorimetry, or DSC, which Dr. Boutron introduced into the field of cryobiology. He also displayed rigorous proof of the absence of ice by X-ray crystallography, or elucidation of the apparent form of ice when ice did form. This paper also introduced the fundamental concept of the existence of critical cooling and warming rates, without which vitrification can hardly even be correctly discussed today. 

Dr. Boutron was also unique in introducing many new candidate cryoprotective agents into consideration, including some, like levo-2,3-butanediol, that inspired much work on the part of others because of its amazing and previously unknown vitrification tendency. He also characterized, with his collaborators, a large number of cryoprotectant solutions, providing a wealth of information that enabled many comparisons to be made between the stability of the amorphous state across very dissimilar solute systems.

However, his pièce de résistance was his fourth theoretical model of the kinetics of ice formation, published in Cryobiology in 1986. The Boutron equation is a kind of cryobiological “theory of everything” that is capable of predicting not only the effect of cooling rate on the quantity of ice formed, but even the shapes of the resulting DSC peaks, and even the shapes and magnitudes of the DSC peaks seen during devitrification upon warming.

One of the criteria for recognition as a CryoFellow is having scientific offspring who have contributed to our field. Dr. Boutron trained Anne Baudot and Patrick Mehl, both of who went on to make significant and even extraordinary contributions to our knowledge of the stability of the amorphous state.

Finally, the lasting contribution of Pierre’s work is reflected in a great many citations and uses of the tools he created. Pierre’s k4 value, now allows us to specify the cooling rate needed to suppress ice formation to any extent we may require for any solution for which k4 is known or can be inferred. The Boutron equation has also allowed critical cooling rates as high as 108 degrees/min and as low as about 1oC/min to be calculated for very dilute or for very concentrated solutions, respectively. We can now calculate the critical warming rate from the critical cooling rate and  we can now compare the warming rates that permit survival after vitrification to the critical warming rates, which opens up many possibilities for future understanding of injury during rewarming.

Finally, you might say that some of Pierre’s legacy offspring were not exactly scientific, but were actual babies, born as a result of vitrifying them as embryos based on the inspiration provided by his discovery of the extreme stability of the amorphous state of propylene glycol. So Dr. Boutron’s legacy lives on in more ways than one, and it is our great pleasure to recognize him as the newest Fellow of the Society for Cryobiology!

Assemble Plus Marine Funding Call



Assemble Plus has opened its second call for access to infrastructure in Marine labs in Europe. 

Assemble Plus funds acess, travel and living expenses for researchers to carry out experiments using marine organisms or equipment available in the marine stations within its member network.

View the Funding Call, check out the FAQ, and visit the Assemble Plus website to find out more information. 

Research Associate in Cryopreservation

University: Newcastle University, United Kingdom 
Location: Newcastle upon Tyne, United Kingdom
Closing Date: 14th September 2018 

For informal enquiries please contact Dr. Roman Bauer
View the Job Description and Postdoc Advertisement
Apply online now

An exciting job opportunity as a Postdoctoral Research Associate is available at Newcastle University, between the Institute of Genetic Medicine (IGM) and the School of Computing (CS). The RA will conduct experimental work in a multidisciplinary team, comprising Dr Roman Bauer (CS), Prof. Majlinda Lako (IGM) and Prof. Evelyne Sernagor (Institute of Neuroscience).

You will work on a project studying the impact of cryopreservation on different kinds of biological tissues. Cryogenic processing protocols will be tested and assessed using a wide range of experimental methods, taking into account anatomy, gene expression and electrical activity. The goal of the project led by Dr Roman Bauer, in collaboration with GE Healthcare and CERN, is to model and improve tissue cryopreservation to yield high-quality post-thaw tissue.

You will hold a PhD in a bioscience discipline and have experience in several experimental techniques, which can be for instance immunohistochemistry, primary cell/tissue culture, qPCR and/or pluripotent stem cell differentiation. Ideally, you will also have experience in at least one electrophysiology method, e.g. in patch clamp or multi-electrode array (MEA) recording.

You will be highly ambitious, have excellent written and spoken English language skills, the ability to present clearly your work, supervise students and collaborate efficiently in a multidisciplinary team. You will have the opportunity to learn new experimental techniques (e.g. organoid growth or MEA recordings from retina), develop leadership skills or quantitative or computational skills if you wish.

The post is funded by the Engineering and Physical Sciences Research Council (EPSRC) and tenable for 32 months on a full-time basis. As part of your application, please provide a CV and covering letter which details your prior experience in experimental work.

CRYO2018 Report 

CRYO2018, which took place July 10-13 at the Spanish National Research Council (CSIC) in Madrid, Spain, was one of the Society's largest meetings in recent memory, attracting 300 abstract submissions and 250 delegates from 35 countries worldwide.

For full details of the program download the electronic copy of the program book and abstract supplement. You can also view all the photos from CRYO2018

Program
The meeting featured 175 oral presentations and over 100 poster presentations, across 5 plenary sessions, 10 symposia, 17 sessions and 2 poster sessions. Alongside traditional sessions exploring cell and tissue preservation, ice formation, tools and technologies, and plant cryopreservation, there were several sessions which stood out as sessions of note. These included three sessions organized jointly with the Organ Preservation Alliance on the current situation and future research required for organ preservation, and cryopreservation of reproductive tissue for cancer survivors. Additionally, due to the expertise of the local organizing committee, the meeting also included sessions on Cryobiology in Food Science and Technology and Challenges in Cryobiology for Microorganisms. 








 













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Election 2018

Nominations are now open for the 2018 election for 3 governors 2019-2021


The nominations committee is now inviting nominations from all Society members in good standing for the position of Governor 2019-2021. There are 3 posts available. 

Please register your interest in standing for election with Nicole Evans by June 1, 2018. A detailed biography and candidate statement outlining your vision for the Society will be requested thereafter. 

The 2018 nominating committee is: 
Adam Higgins (Chair; President-Elect)
Dayong Gao (President)
Greg Fahy (Governor)
Erik Woods (Governor)
Ido Braslavsky (Governor)

Please note all nominations are subject to approval by the nominations committee. This does not affect your right to nomination by petition as outlined in the society's bylaws

Volunteers Required! 

 

The 2018 tactical plan is ambitious and we need your help to accomplish our goals.

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In Memoriam - Alan P. MacKenzie 

The Society for Cryobiology was saddened to hear of the recent passing of Dr. Alan P. MacKenzie, President of the Society for Cryobiology 1977-1978. Dr. MacKenzie was a lifelong supporter and member of the Society, joining in the Society's founding year - 1964, and continuing his affiliation with the Society throughout his lifetime. 

Alan trained in chemistry at the University of London and enjoyed a long career in freeze-drying from 1959. He published more than 60 papers and a number of book chapters on lyophilization, and lectured and taught the subject in both the US and Europe for more than 25 years. He enjoyed a close relationship with the Center for Pharmaceutical Processing Research (CPPR), acting in a number of capacities during their annual meetings, including as keynote speaker on several occasions. 

During his career Alan held posts at the University of Wisconsin in Madison, and from 1976 - 1990 was based at the University of Washington in the School of Medicine, Faculty of Bioengineering. From 1990 onward he consulted full time for the pharmaceutical and diagnostic industries. 

Alan's research interests included aqueous and other solution chemistries, product formulations, freeze-drying cycle development and validation, process scale-up and technology transfer.

Please send remembrances and condolences to Executive Director, Nicole Evans and she will pass them on to Alan's daughter, Sarah, to share with the family.  

Royan Institute Cryobiology and Biobanking Symposium 

The Royan Institute held their second cryobiology and biobanking symposium on Feb. 14, 2018, in Tehran, Iran.

The Royan Institute was established in 1991 as a public non-profit research institute for reproductive biomedicine and infertility treatments. Today Royan consists of three research institutes: 

  • Royan Institute for Stem Cell Biology and Technology (RI-SCBT)
  • Royan Institute for Reproductive Biomedicine (RI-RB)
  • Royan Institute for Biotechnology (RI-B)   

The recent symposium covered advances in basic and applied cryobiology in reproductive biomedicine and stem cells, encompassing cryotechnology, methodology, chemistry, biophysics, cord blood stem cells, and human and animal biobanking. 

16 presentations were given during the one day symposium, including two presentations by invited speaker and Society for Cryobiology immediate Past-President, Jason Acker.  

Society for Cryobiology members Rohoullah Fathi, Mohsen Sharafi, and Maryam Hezavehei, acted as chair, scientific secretary, and executive secretary respectively. 

Download the Symposium Program 

Image Gallery
Click on the thumbnails below to view the high res. image. 










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Society for Cryobiology Profiled in Cold Facts

Cold Facts recently profiled the Society for Cryobiology in the 2018 Buyer's Guide and Corporate Directory issue. 

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Fellow Nominations Open 

CALL FOR CRYOFELLOW NOMINATIONS - DEADLINE APRIL 30


President, Jason Acker, presents President-Elect, Dayong Gao with the CryoFellow Medal at CRYO2017. 

The 2018 CryoFellows Nominations Committee is now soliciting nominations for the appointment of new CryoFellows. This Committee, consisting of three members of the Board of Governors and two CryoFellows, evaluates the nominations and makes recommendations to the Board for approval of new Fellows.

Jan 30: Nominations Open 
April 30: Nominations Close
Week of April 30: Board to vote on nominations at Q2 meeting
July 12: Presentation of Fellow medal at CRYO2018 (dependent on Fellow availability) 

The Society for Cryobiology established an award and medal of CryoFellow just over a decade ago in recognition of members of the society and individuals from the cryobiology community at large who have had an outstanding impact on the field.

CryoFellows are awarded this prestigious status in recognition of: scientific impact of their research on cryobiology (50%); sustained nature of that impact (20%); generation of scientific offspring (20%); and service to the Society (10%).

There is no formal application form on which to make the nomination, but the documents you provide the committee should be of sufficient depth to support the candidate's contributions to the categories mentioned above in a clear and demonstrable way. Usually this will mean inclusion with the nomination:

(1) Supporting letters from members of the Society or other major contributors to cryobiology (including one from the nominator); and 

(2) a detailed resume for the nominee. I suggest you contact the proposed CryoFellow to discuss their nomination before proceeding and to obtain the resume from the nominee.

Please note the nominated individual must be living at the time that he or she is nominated.

If there is someone you would like to nominate, or you would like to have an informal discussion before proceeding with nomination, please email me at [email protected]

ISBER Best Practices Fourth Edition Launch

The International Society for Biological and Environmental Repositories (ISBER) is pleased to announce the release of the ISBER Best Practices, Fourth Edition.

The ISBER Best Practices can be downloaded here: www.isber.org/bestpractices.

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Cryobiology and Biobanking Symposium in Tehran

The Royan Institute is a non-profit research institute for reproductive biomedicine and infertility treatments in Tehran, Iran. On February 14, 2018 they are holding their second Cryobiology and Biobanking Symposium. 

Dr. Jason Acker, immediate Past President of the Society for Cryobiology will be speaking, along with a number of local cryobiology and biobanking experts.  

For more information please contact: 

Vahid Asgari, PhD
Intl' Business Affairs
Consultant and Instructor
[email protected]
+98-9123007955

Click the poster below for more details.

Dayong Gao Assumes Presidency

As cryobiologists, we are entering a new era when cryobiology has a unique and significant contribution and impact on almost every major biomedical research and application area. A once opaque science shrouded in mystery (and liquid nitrogen vapors!) has captured the attention of the public through mainstream news articles on tissue engineering, regenerative medicine, artificial organs, and tissue-organ transplantation. With this diverse range of applications and growing public acknowledgement, this is an exciting time for the field, its scientists and end users, and the Society for Cryobiology.

I inherit a Society whose productivity has flourished during the previous two years under the guidance of my predecessor, Dr. Jason Acker. I could not ask for a better springboard from which to begin my term as President.

Over the next two years I plan to focus on several key areas, including strengthening our ties to other societies and organizations that apply cryobiology in research and practice, such as the Center for Cellular Therapies (AABB), the American Association of Tissue Banks (AATB), the International Society for Cellular Therapy (ISCT), the International Society for Biological and Environmental Repositories (ISBER), among other related societies, through establishing and renewing MOUs, and extending the Society for Cryobiology’s reach through offering cryobiology sessions, workshops or training courses at larger Society conferences.

Membership, a concern for any member based organization, is also at the forefront of my agenda. Over the next year we plan to review, renew and relaunch our corporate and institutional membership scheme and aim to attract young and new-to-the-field investigators to join us as members. Any plan to increase membership requires dedication to long term strategy which will be put into place over the coming year.



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Bylaws Revision Complete

A guest post by Jason Acker  
 
I would like to thank all of you for taking time to participate in the discussions and for voting on the proposed revisions to our Society’s bylaws.  As one of the important documents which guides who we are as a Society and how we choose to operate as an organization, our bylaws need to be up to date and reflect current best practices and laws governing not for profit corporations. The proposed changes were the culmination of more than a decade of discussion, debate and consultation with subject matter experts.

I am happy to report that the motion to ratify the revisions to the Society’s bylaws was carried. The final voter turnout was 59% (153/260 members), with 149 of the voters in favour of adopting the revised bylaws (57% of the membership as a whole). 

I would like to personally thank Jens Karlsson, John Armitage, Art Rowe, John Baust, the members of the Bylaws and Policies Working group (Greg Fahy, Steve Mullen, Andy Picken, Elena Salvaterra), Ed Kordoski, Nicole Evans, our advisors at Maryland NonProfits and all current and past members of the board who have contributed to making this outcome a reality.

I would like to acknowledge that throughout this process there were members who felt strongly that some of the proposed changes were not in the best interest of the Society.  I would like to assure you that your feedback was heard and that it was carefully considered.  Some of the feedback that was received that is not reflected in the revised bylaws will be included in the policies and procedures that are now a focus of the Working Group. 

Now that the Society has established a mechanism for reviewing and updating our bylaws, we should undertake a process to regularly review them and update and adapt them as needed to ensure that they reflect who we are as a Society and how we choose to deliver on the important mission for which our Society was established.

As I transition off of the board and assume my new role as a general member of the Society, I would like to thank all of your for your support during my tenure on the board and as your President. I look forward to continuing to engage with all of you at our scientific meetings and on the various committees and working groups that I may have the privilege of serving on with you.

View the Revised Bylaws

Cryobiology Post-Doc at CDC Foundation 

Entomologist, Biologist or Cryobiologist, Post Doc
Location: Red River Valley Agricultural Research Center
USDA-ARS, Fargo, ND, USA
Closing Date: February 2, 2018
Link: https://www.cdcfoundation.org/jobs/entomologist-biologist-or-cryobiologist-post-doc-941

The CDC Foundation seeks candidates for a full time post-doctoral entomologist, biologist or cryobiologist position to assist with the development of techniques for the cold storage and cryopreservation of mosquitoes. Such techniques may including preparation of egg or larval stages for cryoprotectants permeation, analysis of cryoprotectant toxicity, and vitrification in liquid nitrogen or nitrogen slush. Ancillary methods will include retrieval from cryopreservation, insect rearing and the effects of thermal history on storage success. This laboratory position works 40 hours a week, some of which may consist of part-time weekend and holiday work. The post-doctoral entomologist, biologist or cryobiologist will be hired by the CDC Foundation and assigned to the United States Department of Agriculture (USDA) Agricultural Research Service (ARS) Red River Valley Agricultural Research Center on the campus of North Dakota State University in Fargo, North Dakota.

For more information, including how to apply, download the job specification.  

Senior Engineer in Cancer Immunotherapy 

Company: Kite
Location:
Santa Monica, CA, USA
Closing Date:
Open until filled

Kite, a Gilead company, is a biopharmaceutical company engaged in the development of innovative cancer immunotherapies with a goal of providing rapid, long-term durable response and eliminating the burden of chronic care. The company is focused on chimeric antigen receptor (CAR) and T cell receptor (TCR) engineered cell therapies designed to empower the immune system's ability to recognize and kill tumors.

Kite is seeking a highly motivated individual with fill finish and cryopreservation process engineering experience to work on innovative T cell therapy for cancer treatment. The Senior Engineer will demonstrate deep knowledge of fill finish and cryopreservation, develop robust processes for final drug product formulation, fill finish and cryopreservation for T cell therapy. The Senior Engineer will work with the Early Stage Product Sciences team to design, establish and scale-out cell therapy processes to support early phase clinical trials, manage equipment qualification and support process verification, draft and review protocols, production procedures, process development reports, and provide technical assessment and approval for engineering and process changes pertaining to fill finish and cryopreservation. The Senior Process Engineer will also participate in laboratory activities to support process development and process characterization of Kite’s autologous T cell products.

Download the Job Specification

2018 Officers and Governors Transition

Incoming 2018 Board Members 

First Row: Dayong Gao (President); Adam Higgins (President-Elect); Zhiquan (Andy) Shu (Treasurer)
Second Row: Erik Woods, Ido Braslavsky, Igor Katkov (Governors)

From January 1 Dayong Gao succeeds Jason Acker as President of the Society for Cryobiology. Adam Higgins, current treasurer assumes his new role as President-Elect, and newcomer to the Board, Zhiquan (Andy) Shu, replaces Adam as treasurer. 

The Society's line up of Governors also changes, as we bid farewell to Barbara Reed, Wim Wolkers, and Gang Zhao who have reached the end of their three year term, and welcome newly elected board members Ido Braslavsky and Igor Katkov, and Erik Woods, who has been re-elected. 

Follow Newsnotes over the coming months to get to know our new board members in a series of interviews.