In a recent interview with the Hawaiian Public Radio, Mary Hagedorn, a marine biologist at the Smithsonian Conservation Biology Institute and the Hawaiʻi Institute of Marine Biology, described their ongoing efforts to preserve coral samples for future generations. At its inception, the Hagedorn Lab first froze the sperm and stem cells of two species of coral from Kāneʻohe Bay and currently has 48 coral species preserved from around the world. Society for Cryobiology member, Jessica Bouwmeester describes the process - "Everything is stored at minus 185 degrees Celsius. So we can keep it like that for years, decades, for as long as we need it," Bouwmeester said. International collaboration has provided samples from the Great Barrier Reef, the Caribbean, Hawai'i, Frech Polynesia, and the Gulf of Mexico. But with only 48 out of 1,000 known coral species preserved, they've barely scratched the surface. Read more.

Back from the dead... Bdelloid Rotifers are multicellular microscopic animals with a wheel-like ring of tiny hairs that circle their mouths and that live in freshwater environments. They've been around for about 50 million years. Now, scientists from the Institute of Physicochemical and Biological Problems in Soil Science in Pushchino, Russia have resuscitated rotifers that froze in ancient Siberian permafrost during the latter part of the Pleistocene epoch (2.6 million to about 11,700 years ago). These researchers drilled to 11.5 feet (3.5 meters) below the Siberia Alazeya River surface to collect their samples. The soil was radiocarbon dated at ~24,000 years old. Once thawed in the lab, these "zombie" rotifers reanimated and began reproducing asexually through parthenogenesis and created clones that were their genetic duplicates. Read the full new article...

Scientists at UC Santa Barbara, University of Southern California (USC), and the biotechnology company Regenerative Patch Technologies LLC (RPT) have discovered a new method for preserving RPT's stem cell-based therapy for age-related macular degeneration (AMD), the leading cause of blindness in aging populations. This new research uses a flexible scaffold, about 18 mm², to optimize the cryopreservation of a single layer of ocular cells generated from human embryonic stem cells. Currently in clinical trials, this implant can be frozen, stored for long periods, distributed to clinical sites, then thawed and immediately implanted into the patient's eyes. The extended shelf-life and on-demand distribution will increase the number of patients who can benefit from this treatment. Read the full article. 

 The Drosophila melanogaster fruit fly, a critical genetic research model, has eluded scientist's attempt to cryopreserve the embryos until now. A research team from the University of Minnesota and Center for Advanced Technologies for the Preservation of Biological Systems (ATP-Bio) including Society for Cryobiology members Drs. Le Zhan and John Bischof, introduce a new method of cryopreserving Drosophila embryos with >50% of the embryos hatching post cryopreservation and >25% of the resulting larvae maturing to full adults. According to the Society for Cryobiology member Dr. John Bischof "Our multi-disciplinary team is pleased to contribute an accessible protocol to cryopreserve numerous strains of Drosophila, an important biomedical model, while also hopefully informing other insect and related species embryo preservation." Humans share more than 50% of their genes with the Drosophila, and these seemingly insignificant flies have already been vital for Alzehimer or Zika research. Read the news article or the original research abstract.

Improved cryopreservation of embryos in the field of IVF would increase fertility odds for Would-Be parents and the health of their future babies. A research collaboration between the National Institute of Genetic Engineering and Biotechnology in Iran and McGill University and the University of British Columbia in Canada introduce an independent, automated microfluidic system to replace the water with cryoprotectants (CPAs) during the embryo vitrification process. Traditional CPA pipetting techniques can result in abrupt osmotic shock causing molecular damage to the embryos. In this new method, the embryos are placed on a chip that automatically controls the CPA's concentration and flow rate, significantly reducing potential human error. Read the full news article or the Biomicrofluidics abstract.

A research team from Huazhong University of Science and Technology and Wuhan Union Hospital have developed a new medium, named Cryogel, to reverse osteoarthritis in mice with slow releasing stem cells. This sponge-like material is created at subzero temperatures and is extremely porous. After seeded the Cryogel with mesenchymal stem cells (MSCs), it is implanted at the affected joint. "It takes about two weeks for half of the implanted cells to leave, but their regenerative effects stick around for longer," said corresponding author Wei Tong from the Department of Orthopedics of Union Hospital. "So it is possible that the therapeutic result comes indirectly, via the stem cells secreting epidermal growth factors, which stimulate cell proliferation and healing, rather than directly becoming newly formed cartilage in the joint." The team also reports that this technique reduces the required stem cell amount by 90%. Read the news article or the original abstract published in Chemical Engineering Journal.

An ambitious project to create a human "Organ Bank", the Biostasis Research Institute (BRI), is underway in conjunction with the Massachusetts General Hospital and the University of Minnesota. Society for Cryobiology member, co-founder and Director of the BRI, Jedediah Lewis, says "This institute is another major step forward in the ability to store life. These technologies can bring to science and medicine what other domains, such as energy and agriculture, have taken for granted for centuries: practical, widespread distribution of humanity's most important lifesaving resources. The benefits for human health will be profound." Society for Cryobiology members Dr. Korkut Uygun and Dr. Shannon Tessier are part of the leadership team for the Center for Biostasis at Massachusetts General Hospital, one of two research facilities to be built, which will develop and apply new technologies for controlling ice formation at sub-freezing temperatures and create living systems able to undergo extreme temperature changes. Society for Cryobiology member Dr. John Bischof is part of the leadership team for the other research center, the Organ and Tissue Preservation Center at the University of Minnesota, which will focus on new reanimation technologies to restore and revive the cryopreserved organs. The BRI's three initial objectives are preserving organs for infants and children in need of a transplant, creating the first functional human brain banks, and extending the storage time of kidney transplants from days to weeks. Read the full article.

The international team of scientists and researchers from the Leibniz Institute for Zoo and Wildlife Research are pleased to announce the introduction of four new northern white rhino (NWR) embryos, totaling nine embryos ready for implantation into surrogate southern white rhinos (SWRs). Oocytes (immature egg cells) were collected from Fatu, one of the two last remaining NWR, and artificially inseminated using frozen sperm from deceased NWR males. The team is currently preparing the family environment including carefully selecting potential surrogate SWR and sterilizing Owuan, a SWR male, whose behavior will provide key indicators to the surrogate's reproductive timing. Read the full article...

The nominations committee is now inviting expressions of interest from all Society members in good standing for the following positions

• President-Elect (2022 - 2023) --> President (2024-2025)
• Treasurer (2022 - 2023)
  
• Secretary (2022 - 2023)
• 3x Governors (2022 - 2024) 

The President-Elect, Treasurer, and Secretary form the Society for Cryobiology's Executive Committee, along with the President and Executive Director. They hold monthly meetings to discuss current Society business. They also partake in the quarterly Board of Governors meetings, and other duties outlined below. Specifics relating to these roles can be found in the Society's bylaws. 

Society for Cryobiology Governors take an active role in the decision making that guides the Society. Governors participate in quarterly Board meetings and take on leadership responsibilities in various Society committees. They may also be involved in leadership roles in other Society activities of their interest, for example the Annual Meeting, or ad hoc projects. 

To express your interest or for an informal discussion regarding the various roles please email Executive Director, Nicole Evans. Please note all nominations are subject to approval by the nominations committee. This does not affect your right to nomination by petition as outlined in the Society's bylaws. 

If your candidate nomination is accepted or you are nominated by petition you will be required to provide a detailed biography, statement outlining your vision for the Society, and a photograph for the election materials. 

The deadline to express your interest in standing as a candidate for Governor is Monday August 16, 2021. The election will be held October 11-25, 2021.

WEBINAR - ENDING COVID-19: THE VACCINE, TECHNOLOGY, AND LOGISTICS CHALLENGES

Feb. 18, 2021 11AM PT / 2PM ET / 8PM CET / 3AM NEXT DAY CST

Fellow Nominations Open 

CALL FOR CRYOFELLOW NOMINATIONS - DEADLINE MAY 31


Past - President, Jason Acker, presents Past-President Dayong Gao with the CryoFellow Medal at CRYO2017. 

The CryoFellows Nominations Committee is now soliciting nominations for the appointment of new CryoFellows. This Committee, consisting of three members of the Board of Governors and two CryoFellows, evaluates the nominations and makes recommendations to the Board for approval of new Fellows.

Jan 30: Nominations Open 
May 31: Nominations Close
June - mid-July: Evaluation of nomination materials by Fellow Committee
July 20: Board of Governors to vote on Fellow Committee recommendations


The Society for Cryobiology established an award and medal of CryoFellow just over a decade ago in recognition of members of the society and individuals from the cryobiology community at large who have had an outstanding impact on the field.

CryoFellows are awarded this prestigious status in recognition of: scientific impact of their research on cryobiology (50%); sustained nature of that impact (20%); generation of scientific offspring (20%); and service to the Society (10%).

There is no formal application form on which to make the nomination, but the documents you provide the committee should be of sufficient depth to support the candidate's contributions to the categories mentioned above in a clear and demonstrable way. Usually this will mean inclusion with the nomination:

(1) Supporting letters from members of the Society or other major contributors to cryobiology (including one from the nominator); and 

(2) a detailed resume for the nominee. I suggest you contact the proposed CryoFellow to discuss their nomination before proceeding and to obtain the resume from the nominee.

Please note the nominated individual must be living at the time that he or she is nominated.

If there is someone you would like to nominate, or you would like to have an informal discussion before proceeding with a nomination, please email me at [email protected]. 

Vancouver-January 12, 2021--The International Society for the Biological and Environmental Repositories (ISBER), which represents professional experts in biobanking, ultra-low temperature (ULT) storage, and cold chain management, has released its position statement listing key practices health agencies should consider to support the COVID-19 vaccine distribution with dedicated ULT freezers. The document, titled "Ultra Low Temperature Freezers: Key Considerations," provides evidence based guidance for those responsible for distribution, storage, and management of the vaccine, to resources that detail the fundamentals of safe and efficient ULT freezer management, shipping, and distribution.

"The global biobanking community has consolidated our knowledge and expertise into a brief one page resource. We aim to minimize the learning curve and to help people and health agencies new to ultra-low temperature storage avoid common pitfalls," said Piper Mullins, President-Elect of ISBER.

The document draws on accepted practices known to ensure robust ULT product storage and distribution that are routinely used by biorepositories. The document represents a consensus view from the biobanking community. The organization drew on the expertise of biorepository managers and industry vendors with further reference from the ISBER Best Practices, Fourth Edition. The statement intends to supplement guidance from national and local health agencies on managing the cold chain deployment of frozen COVID-19 vaccines.

 "We want ISBER to be the go-to resource for the growing number of people who are just learning about ultra-low storage and handling during this fraught time," said Associate Professor Daniel Catchpoole, President of ISBER. "As a scientific community who are experts in cold chain logistics of biological specimens, it is vital that our national health agencies draw on the expertise ISBER provides to guide the proper management of freezers for the distribution of biological therapeutics." 

To learn more about the association please visit www.isber.org.

About the International Society for Biological and Environmental Repositories

ISBER (www.isber.org) is the only global forum that addresses harmonization of scientific, technical, legal, and ethical issues relevant to repositories of biological and environmental specimens. ISBER fosters collaboration; creates education and training opportunities; provides a forum for the dissemination of state-of-the-art policies, processes, and research findings; and provides an international showcase for innovative technologies, products, and services. Together, these activities promote best practices that cut across the broad range of repositories that ISBER serves.

About the ISBER Best Practices

The ISBER Best Practices: Recommendations for Repositories Fourth Edition presents the most effective practices for the management of biological and environmental specimen collections and repositories. These are either evidence-based or consensus-based practices for collection, long-term storage, retrieval, and distribution of specimens. Development of best practices is a rigorous, consensus-based process that reflects advances in research and technology. To access, please visit: https://www.isber.org/page/BPR.

New Fellows Announced

The Board of Governors is pleased to announce the recent approval of two new Fellows of the Society for Cryobiology: Erik Woods and Art DeVries. Erik and Art will be presented with their Fellow medals during a special session at CRYO2021, held in Chicago, July 20-23, 2021. 


Erik Woods

Society for Cryobiology 2020 Election Results 

Executive Director, Nicole Evans, and myself are pleased to announce the results of the Society for Cryobiology 2020 Election for 3 Governors-at-Large 2021-2023.

The new Governors are:

John M. Baust, CPSI Biotech, USA
Shannon N. Tessier, Massachusetts General Hospital and Harvard Medical School, USA
Christina Walters, USDA-ARS National Laboratory for Genetic Resources Preservation, USA

To learn more about the new governors you can download their biographies and vision statements on the Society for Cryobiology website.

Together these newly elected Governors are truly representative of the many cryo sectors, representing industry, academia, and government. 

I would like to extend a sincere thank you to all the candidates who stood for election, and to all members who took the time to vote. Voter turnout this year was 49%.  This is on par with last year, which came in at a 48% turnout.

If you have any questions or comments please do not hesitate to contact myself or Nicole.

With Best Wishes,
Adam Higgins
President
Society for Cryobiology

2020 Election

The Society for Cryobiology 2020 election will be held October 12 - 26, 2020. The election is for three Governor-at-Large positions for a term commencing January 2021 and ending December 2023. 

All members in good standing will receive an email in advance of the election to the email address listed in their member profile. The email will contain a personalized one-time use voting link to cast your vote anonymously at simplyvoting.com. If you do not receive your voting email within 24 hours of the election opening please check your spam folder and then contact [email protected] urgently. 

Voting Method 
Each voter is assigned 100 points to allocate to one or more candidates e.g. a voting member could give one candidate all 100 points, or divide points between any number of selected candidates.  All candidates are ranked by total number of points received, with the top 3 candidates named as the winners. 

Meet the Candidates 

Although a standard practice in many European countries, a medical team in Hong Kong used the Organ Care System for the first time on a human heart transplant. Invented in the USA, the Organ Care System is superior to traditional ice boxes for transporting organs by keeping the heart warm and beating with oxygenated blood up to 10 hours. Dr Timmy Au Wing-kuk, chief of Queen Mary Hospital’s cardiothoracic surgery department where the medical procedure was performed, says the implementation of the Organ Care System can increase the number of successful transplants by 5 to 10 each year. This transport method also allows medical teams to use hearts that would have been disqualified previously due to donor's age, organ condition, or travel distance. Read More...

Governor Nominations Open

The nominations committee is now inviting expressions of interest from all Society members in good standing for the position of Governor 2021-2023. 

Society for Cryobiology Governors take an active role in the decision making that guides the Society. Governors participate in quarterly Board meetings, and take on leadership responsibilities in various Society committees. They may also be involved in leadership roles in other Society activities of their interest, for example the Annual Meeting, or ad hoc projects. 

To express your interest please email Chair of the Nominating Committee, President Elect Dr. Greg Fahy. Please note all nominations are subject to approval by the nominations committee. This does not affect your right to nomination by petition as outlined in the society's bylaws. 

If your candidate nomination is accepted you will need to provide a detailed biography, statement outlining your vision for the Society, and a photograph for the election materials. 

The deadline to express your interest in standing as a candidate for Governor is September 14, 2020. The election will be held October 12-26, 2020.

The 2020 nominating committee is: 

Greg Fahy (Chair, President-Elect)
Adam Higgins (President)
Steven Mullen (Treasurer)
Erik Woods (Governor)
Ido Braslavsky (Governor)

Over the past six years, researchers from the Okinawa Institute of Science and Technology Graduate University (OIST) have developed an easier and cheaper version of the traditional cryo-electron microscope (cryo-EM). Opposed to the traditional high-energy electron cryo-EM, this new style utilizes a low-energy electron beam. The low-energy electron cryo-EM allows scientists to better observe atoms with low atomic mass such as carbon, oxygen, hydrogen, which are primary elements in biomolecules. Another benefit to this new cryo-EM is the ability for scientists to observe both amplitude and phase whereas the traditional method only provides information on phase. Drawbacks include an image resolution significantly inferior to a conventional cryo-EM, but researchers could use this new method to gauge their sample quality before proceeding to the more costly, high-energy electron method. READ MORE