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Organ Preservation Postdoc

Organ Preservation Postdoc 

Job Title: Postdoctoral Fellow
Location: Center for Engineering in Medicine
Massachusetts General Hospital & Harvard Medical School  
Closing date: December 2017

CEM is affiliated with Massachusetts General Hospital & Harvard Medical School & Shriners Hospital and houses 6 senior and ~10 junior PIs along with  a research staff >50; it’s also the home to the BioMems Resource Center . The research in the hospital is funded by NIH, NSF, DOD, Shriners, MGH as well as industry.

 More info on CEM can be found at http://www.massgeneral.org/cem/ and http://cem.sbi.org/web/index.htm

Description: We are looking for a talented Postdoctoral Fellow to contribute to our work on whole organ preservation for the purpose of transplantation.

Description of the project: The field of transplantation is facing a serious donor shortage crisis. The World Health Organization estimates organ transplants are meeting less than 10% of global demand. Of critical importance, the field of transplantation suffers from ineffective bio-preservation and stabilization protocols resulting in a short amount of time - currently hours - which organs can be kept alive ex vivo. This creates an inherent bottleneck in the system: most directly, improvement of current organ preservation practices has the potential to improve organ quality, enabling the use of currently discarded organs, decreasing the incidents of graft failure, and extending the in vivo lifetime of the transplanted organ. Further, longer storage durations would enable HLA typing and global matching programs, therefore improving transplantation outcomes, and reducing the burden of immunosuppressive therapy. Similarly, extending ex vivo organ preservation duration will allow for more complete quality control analyses thereby providing more time for complex clinical decisions, reducing unnecessary waste of quality organs, and alleviating concerns about disease transmission between donor and recipient.

Desired Skills and Experience: We are looking for highly motivated and hardworking Postdoctoral Fellows with diverse backgrounds to join our highly interdisciplinary team. Example tasks include (but are not limited to) operation of machine perfusion equipment, solution formulation, cell culture, microscopy and histology, and molecular assays (e.g. ELISAs, qPCR, etc.). The candidate will be supervised by faculty or senior research staff, will be involved in research projects, and expected to contribute and lead research papers.

Expertise in cryobiology, drug delivery, nanotechnology, or biomaterials are examples of highly desirable skills. Also, experience with perfusion technology, live animal handling, cell culture, and molecular assays are added benefits.  

Contact Person: Applications should be sent to both [email protected] (Dr. Mehmet Toner) and [email protected] (Dr. Korkut UYGUN) with the subject line “Postdoc: Organ preservation”.

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