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If you would like to advertise a vacancy on this page please contact the Society for Cryobiology's editorial office at cryobiology@beds.ac.uk.


POSTDOCTORAL POSITION IN CRYOBIOLOGY
Hubbard Lab

The Hubbard lab (Department of Pharmacology, University of Alberta) is seeking a postdoctoral fellow to join their dynamic and enthusiastic research team. The successful candidate will work on a cryobiology project to assess the biochemical and biophysical properties of novel synthetic cryoprotective compounds, and examine their cryoprotective capacity in human cells, tissues, and possibly even organs (long-term objective). This project is part of a multidisciplinary collaboration being developed in conjunction with researchers in the Alberta Glycomics Centre. Techniques that will be employed include: nanolitre osmometry (to measure thermal hysteresis), ice recrystallization inhibitor (IRI) assays, primary and non-primary cell culture, various cell proliferation and viability assays (e.g. assessing RBC viability – Drabkin’s method), and optimizing freezing protocols using our programmable freezer. Longer-term objectives will involve dissection of murine tissues for cryopreservation, and subsequent assay of tissue damage and viability. In addition, the postdoc will have the opportunity to work on a second project investigating the mammalian genetics underlying cryopreservation. This position is for one year renewable for up to four years, depending on funding availability.

Basic qualifications:

  • Candidate must be within 0-24 months of completing their PhD degree in a discipline related to molecular biology/biochemistry or cryobiology
  • Candidate must have a record of scientific productivity and a minimum of 1 first-author publication in an impactful journal (IF>5) or a highly regarded subject specific journal (e.g. Cryobiology, Journal of Virology, etc.);
  • Excellent written and oral communication skills (English)
  • Experience in basic molecular biology techniques (cloning, PCR, western blot, etc.), and biochemistry
  • Expertise in cryobiology is preferred but not essential
  • Self-motivated individual, able to work independently, in collaborations and in multidisciplinary teams

To Apply:
Please send a cover letter describing your research interests, career goals, and a summary of your relevant research experience, as well as a copy of your CV and contact information of three references to:

Dr. Basil Hubbard
bphubbard@ualberta.ca

Closing date:
Position open until filled.

Expected Start Date:
January, 2017

We thank all applicants for their interest; however, only those individuals selected for an interview will be contacted.

The University of Alberta offers appointments on the basis of merit. We are committed to the principle of equity in employment. We welcome diversity (applications from all qualified women and men, including persons with disabilities, members of visible minorities and Aboriginal persons, etc.); International applications are welcomed, but in accord with immigration laws, Canadians and permanent residents will be given priority.

Date Posted on SfC website: 11/11/2016


 

Postdoctoral Position (posted October 2016)
Biostabilization and Bioencapsulation Laboratories, Mechanical Engineering Department
University of Minnesota, Minneapolis, MN

A post-doctoral position is available immediately at the Biostabilization and Bioencapsulation Laboratories (http://biogels.umn.edu) at the Department of Mechanical Engineering at University of Minnesota. The position is focused on developing a novel method for room temperature stabilization and storage of human biospecimens, with specific emphasis on storage stabilization of proteinaceous cancer biomarkers.

Room temperature stabilization by isothermal vitrification requires less stringent processing and storage requirements for biospecimen processing, transport, and storage resulting in significant cost savings. Isothermal vitrification also helps avoid the physical, thermal, and chemical stresses imposed on macromolecules during processing and cryogenic storage, ensuring that the molecular information content of the biospecimens are preserved. Our group has developed an adsorbing/dissolving lyoprotectant matrix, and a complementary isothermal vitrification procedure to stabilize human serum (see a recent publication from our
group on this research at http://www.nature.com/articles/srep24186). During the developmentstage of this research, we have established post-storage information recovery of >90% for the five model serum biomarkers studies. We are currently in the validation stage of the project where further characterization and long-term stabilization studies are being conducted in collaboration with Mayo Clinic in Rochester, MN with the goal of validating the method for +300 serum biomarkers; a crucial bottleneck for success.

We are looking for a highly motivated individual with a Ph.D. in Biochemistry, Chemistry, Chemical Engineering, Biomedical Engineering or Molecular Biology (or in a related field) with demonstrated competence, relevant expertise and having published high impact, innovative research publications. Experience in biospecimen science, and/or protein stabilization is desirable but not necessary. 

The post-doctoral associate is expected to perform long term storage stability studies, and
accelerated aging studies using the developed matrix and the methodology, identify possible causes of destabilization/degradation/damage in individual biomarkers and protein families, and develop strategies for improvement. Technical expertise in standard basic molecular analysis techniques such as gel electrophoresis, Western blot, enzyme activity assays, and other protein assays are absolutely required. Knowledge of protein software such as The Basic Alignment Tool (BLAST) and ExPasy are desirable but not required. Experience with physical/chemical characterization techniques such as FTIR, CD, DSC, XRD, etc. is very important.

Candidates must be enthusiastic and dedicated to science with excellent organizational skills and effective at working independently, while also collaborating and assisting the team reaching its collective research goal. Excellent verbal and written communication skills are required.

Application documents must be submitted online through the UMN employment system at: http://humanresources.umn.edu/jobs. Click on External Faculty and Staff Applicants, enter "313374" in the Job Opening ID, and change the Jobs Posted Within drop down menu to "anytime." At this point a username and password will need to be created to access thesystem.